Odontoblast differentiation: a response to environmental calcium?
نویسندگان
چکیده
منابع مشابه
Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation.
Formation of calcified tissues is a well regulated process. In dentin, the odontoblasts synthesize several biomolecules that function as nucleators or inhibitors of mineralization. To identify genes that are odontoblast-specific, a subtractive hybridization technique was employed that resulted in the identification of a previously undescribed novel gene synthesized by the odontoblasts. Based on...
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Tunicamycin (TM), an antibiotic that selectively inhibits dolichol-mediated protein glycosylation, inhibited morphogenesis and differentiation of odontoblasts in the molar tooth germ in vitro. These effects of TM are reversible and dose-dependent, and in advanced teeth the effect of TM was not complete unless the basement membrane was removed prior to culture. TM did not prevent secretion of pr...
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ژورنال
عنوان ژورنال: Dental Traumatology
سال: 1998
ISSN: 1600-4469,1600-9657
DOI: 10.1111/j.1600-9657.1998.tb00821.x